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WHO Classification of Tumours
Acquired cystic disease-associated renal cell carcinoma


ACD-associated RCC has been reported to be the most frequent tumours in
patients with end-stage renal disease (ESRD) caused by acquired cystic
diease. They were not observed in patients with non-cystic ESRD.

The following criteria have been listed as distinguishing this lesion from
papillary RCC

Click to access Pubmed
Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, Moch H, Amin MB (2006)
Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia.
Am J Surg Pathol 30: 141-53

>> a unique focal or diffuse cribriform architecture (in 96% tumors)
>> the consistent presence of eosinophilic cells in tumors with grade 3 nuclei, and
>> the frequent presence of intratumoral oxalate crystals.