logo logo
Search: Organ site Search: Tumor / Syndrome
WHO Classification of Tumours
Giant cell malignant fibrous histiocytoma
Connective, subcutaneous and other soft tissues


Giant cell malignant fibrous histiocytomas (MFHs) are undifferentiated, pleomorphic sarcomas with prominent osteoclastic giant cells. They typically occur in deep soft tissue of limbs and trunk. Most giant cell MFHs are large, high grade tumours with haemorrhage and necrosis. Histologically, the tumours are characterized by pleomorphic ovoid- to spindle-shaped cells and a prominent stromal osteoclastic giant cell reaction. In most cases, the giant cell component lacks cytological features of malignancy, but occasionally, numerous bizarre multinucleate tumour giant cells can be observed.
Giant cell MFH is a very uncommon tumour. It predominantly arises in older adults and is rare in children and adolescents. The prognosis is similar to that of other pleomorophic sarcomas

Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002