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WHO Classification of Tumours
Cellular angiofibroma
Connective, subcutaneous and other soft tissues


Definition

Cellular angiofibroma (CA) is a rare benign mesenchymal lesion typically arising in the superficial soft tissues of the vulva and in the inguinoscrotal region. In the vulva, tumours usually measure less than 3cm, whereas tumour size in men ranges from 2.5 to 14 cm. Histologically, CA is characterized by spindle-shaped cells, scattered mast cells, fine collagenous fibres and perivascular hyaline fibrosis. The lesions appear as well circumscribed, highly cellular and richly vascularised nodules. Nearly 50% of cases contain fat, generally near the tumour periphery
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Cellular angiofibroma occurs in adults with a peak incidence from the 5th to 7th decades of life. Local excision is usually curative

Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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