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WHO Classification of Tumours
Adult fibrosarcoma
Connective, subcutaneous and other soft tissues


Definition

Adult fibrosarcoma is a malignant fibroblastic tumour arising from deep soft tissues mainly in extremities, trunk, and head and neck region. It is histologically characterized by spindle-shaped fibroblasts, collagen production and a herringbone pattern. In high grade tumours, haemorrhage and necrosis are common. The lesions are typically circumscribed masses and variably firm in relation to the collagen content
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Classical fibrosarcoma occurs most frequently in middle-aged and older patients. Local recurrence rates depend on the completeness of excision. Metastases occur in up to 63% of patients and develop in lungs, bones and rarely in lymph nodes. The overall 5-year survival is 39-54%

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Pritchard DJ, Soule EH, Taylor WF, Ivins JC (1974)
Fibrosarcoma--a clinicopathologic and statistical study of 199 tumors of the soft tissues of the extremities and trunk.
Cancer 33: 888-97




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Scott SM, Reiman HM, Pritchard DJ, Ilstrup DM (1989)
Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases.
Cancer 64: 925-31




Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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