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WHO Classification of Tumours
Myxoinflammatory fibroblastic sarcoma
Connective, subcutaneous and other soft tissues


Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low grade sarcoma that predominantly arises in hands and wrists (two-thirds of cases), followed by feet and ankles. MIFS generally invades the subcutaneous fat, frequently also the dermis, and often involves joints and tendons. The tumours are typically poorly defined and multinodular with a size range from 1 to 8 cm (median 3-4 cm). Histologically, they are characterized by a prominent dense inflammatory infiltrate associated with alternating hyaline and myxoid areas. The main types of neoplastic cells are spindled cells, large ganglion-like cells, and multivacuolated lipoblast-like cells.
MIFS occurs primarily in adults with a peak incidence in the fourth and fifth decades. Reported local recurrence rates vary from 20-70%; metastases are extremely rare

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002