Connective, subcutaneous and other soft tissues
Gardner fibroma is a benign neoplasm that arises in the superficial and deep soft tissues of the paraspinal region, back, chest wall, flank, head and neck, and extremities. The tumours are poorly circumscribed and range in size from 1 to 10 cm. As nuchal-type fibromas
, they consist of thick, haphazardly arranged collagen bundles with interspersed bland fibroblasts. At the tumour periphery, the collagen infiltrates adjacent tissues and entraps fat, muscle, and nerves.
Gardner fibroma is an uncommon lesion that affects predominantly infants, children, and adolescents. More than 90% of the reported cases were associated with Gardner syndrome
, a variant of familial adenomatous polyposis, caused by germline mutations of the APC gene. Approximately 45% of Gardner fibroma patients develop subsequent desmoid-type fibromatoses
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
IARC Press: Lyon 2002