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WHO Classification of Tumours
Calcifying aponeurotic fibroma
Connective, subcutaneous and other soft tissues


Definition

Calcifying aponeurotic fibroma (CAF) is a rare, slowly growing benign neoplasm that arises near tendons, fascia and aponeuroses, typically in palms and soles, wrists and ankles. The tumours present as small (usually <3cm), poorly circumscribed, infiltrative masses. Characteristic histologic features are foci of calcification surrounded by a palisade of rounded cells and radiating fibroblasts.
CAF is very rare. It mainly affects children (median age, 12 years) and shows a slight predilection for males. The tumour is not destructive, but local recurrence occurs in up to 50% of cases, particularly in children <5 years of age. The lesion shows reduced growth with age

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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