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WHO Classification of Tumours
Desmoplastic fibroblastoma
Connective, subcutaneous and other soft tissues


Desmoplastic fibroblastoma is a rare, benign neoplasm that arises in a variety of sites, most frequently in arm, shoulder, lower limb, back, hand and foot. The tumours present as usually small (1-4cm), well circumscribed and sometimes lobulated masses that typically involve the subcutaneous fat. In 25% of cases, they extend into the skeletal muscle. Histologically, desmoplastic fibroblastomas are characterized by scattered spindle- or stellate-shaped fibroblasts and myofibroblasts and a densely collagenous stroma.
Desmoplastic fibroblastoma occurs with a peak incidence between the fifth and seventh decades of life. Approximately 75% of patients are males. The tumours do not metastasize and do not recur

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002