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WHO Classification of Tumours
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
Tumours of haematopoietic and lymphoid tissues


Definition

B-cell lymphomas with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) are aggressive lymphomas that have morpho­logical and genetic features of both DLBCL and BL, but for biological and clinical reasons should not be included in these categories. Some of these cases were previously classified as Burkitt-like lymphoma (BLL).

The majority of the cases in this category have morphological features that are ­intermediate between DLBCL and BL (Table 10.18), with some cells that are smaller than typical DLBCL, resembling BL, and some cells that are larger than typical BL, resembling DLBCL, as well as a high proliferation fraction, starry-sky pattern, and an immunophenotype consistent with BL. Some cases may be morphologically more typical of BL but have an atypical immunophenotype or genetic features that preclude a diagnosis of BL. The diagnosis of this type of unclassifiable B-cell lymphoma category should not be made in cases of morphologically typical DLBCL that have a MYC rearrangement, or in otherwise typical BL in which a MYC rearrangement cannot be demonstrated. Some transformed follicular lymphomas may fall into this category. This is a heterogeneous category that is not considered a distinct disease entity, but is useful in allowing the classification of cases not meeting criteria for classical BL or DLBCL.

> Related Topics
Burkitt lymphoma
Diffuse large B-cell lymphoma
Introduction: Classification of lymphoid neoplasms