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WHO Classification of Tumours
Classical Hodgkin lymphoma type PTLD
Tumours of haematopoietic and lymphoid tissues


Definition

Classical Hodgkin lymphoma (CHL), the least common major form of PTLD, occurs in the post-transplant setting, most often in renal transplant patients, is almost always EBV-positive and should fulfill the criteria for CHL as described (See Chapter 12). Because Reed-Sternberg-like cells may be seen in early, polymorphic and some monomorphic PTLD, the diagnosis of HL must be based on both classical morphologic and immunophenotypic features, preferably including both CD15 and CD30 expression
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Nalesnik MA, Randhawa P, Demetris AJ, Casavilla A, Fung JJ, Locker J (1993)
Lymphoma resembling Hodgkin disease after posttransplant lymphoproliferative disorder in a liver transplant recipient.
Cancer 72: 2568-73




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Rowlings PA, Curtis RE, Passweg JR, Deeg HJ, Sociť G, Travis LB, Kingma DW, Jaffe ES, Sobocinski KA, Horowitz MM (1999)
Increased incidence of Hodgkin's disease after allogeneic bone marrow transplantation.
J Clin Oncol 17: 3122-7



. Although CD15-negative cases occur, caution is advised in making the diagnosis of CHL-type PTLD as these cases must be distinguished from Hodgkin-like lesions, in which the EBV+ Reed-Sternberg-like cells are CD45+, CD15-, CD20+ and where one may find small and intermediate-sized EBV+ lymphoid cells as well
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Chetty R, Biddolph S, Gatter K (1997)
An immunohistochemical analysis of Reed-Sternberg-like cells in posttransplantation lymphoproliferative disorders: the possible pathogenetic relationship to Reed-Sternberg cells in Hodgkin's disease and Reed-Sternberg-like cells in non-Hodgkin's lymphomas and reactive conditions.
Hum Pathol 28: 493-8




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Doyle TJ, Venkatachalam KK, Maeda K, Saeed SM, Tilchen EJ (1983)
Hodgkin's disease in renal transplant recipients.
Cancer 51: 245-7




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Goyal RK, McEvoy L, Wilson DB (1996)
Hodgkin disease after renal transplantation in childhood.
J Pediatr Hematol Oncol 18: 392-5




Click to access Pubmed
Nalesnik MA, Randhawa P, Demetris AJ, Casavilla A, Fung JJ, Locker J (1993)
Lymphoma resembling Hodgkin disease after posttransplant lymphoproliferative disorder in a liver transplant recipient.
Cancer 72: 2568-73




Click to access Pubmed
Pitman SD, Huang Q, Zuppan CW, Rowsell EH, Cao JD, Berdeja JG, Weiss LM, Wang J (2006)
Hodgkin lymphoma-like posttransplant lymphoproliferative disorder (HL-like PTLD) simulates monomorphic B-cell PTLD both clinically and pathologically.
Am J Surg Pathol 30: 470-6




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Ranganathan S, Webber S, Ahuja S, Jaffe R (2004)
Hodgkin-like posttransplant lymphoproliferative disorder in children: does it differ from posttransplant Hodgkin lymphoma?
Pediatr Dev Pathol 7: 348-60



. Rare cases may follow other types of PTLD. Although the distinction of Hodgkin-like P-PTLD from true Hodgkin type PTLD may be difficult in some cases, the former are better characterized as either a polymorphic or monomorphic PTLD, depending on their overall morphologic features
Click to access Pubmed
Pitman SD, Huang Q, Zuppan CW, Rowsell EH, Cao JD, Berdeja JG, Weiss LM, Wang J (2006)
Hodgkin lymphoma-like posttransplant lymphoproliferative disorder (HL-like PTLD) simulates monomorphic B-cell PTLD both clinically and pathologically.
Am J Surg Pathol 30: 470-6




Click to access Pubmed
Ranganathan S, Webber S, Ahuja S, Jaffe R (2004)
Hodgkin-like posttransplant lymphoproliferative disorder in children: does it differ from posttransplant Hodgkin lymphoma?
Pediatr Dev Pathol 7: 348-60



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> Related Topics
Introduction: Post-transplant lymphoproliferative disorders (PTLD)
Classical Hodgkin lymphoma
Introduction: Classification of lymphoid neoplasms