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WHO Classification of Tumours
Chronic lymphoproliferative disorder of NK-cells
Tumours of haematopoietic and lymphoid tissues


Chronic lymphoproliferative disorders of NK cells are rare and heterogeneous. They are characterized by a persistent (>6 months) increase in peripheral blood (PB) NK cells (usually ≥2x109/L) without a clearly identified cause. It is difficult to distinguish between reactive and neoplastic conditions without highly specialized techniques. Chronic NK-cell lymphoproliferative disorder (CLPD-NK) represents a proliferation of NK cells associated with a chronic clinical course, and is considered a provisional entity.

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