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WHO Classification of Tumours
Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma of the elderly
Tumours of haematopoietic and lymphoid tissues


Definition

EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is an EBV+ clonal B-cell lymphoid proliferation that occurs in patients >50 years and without any known immunodeficiency or prior lymphoma
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Oyama T, Ichimura K, Suzuki R, Suzumiya J, Ohshima K, Yatabe Y, Yokoi T, Kojima M, Kamiya Y, Taji H, Kagami Y, Ogura M, Saito H, Morishima Y, Nakamura S (2003)
Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients.
Am J Surg Pathol 27: 16-26




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Oyama T, Yamamoto K, Asano N, Oshiro A, Suzuki R, Kagami Y, Morishima Y, Takeuchi K, Izumo T, Mori S, Ohshima K, Suzumiya J, Nakamura N, Abe M, Ichimura K, Sato Y, Yoshino T, Naoe T, Shimoyama Y, Kamiya Y, Kinoshita T, Nakamura S (2007)
Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients.
Clin Cancer Res 13: 5124-32




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Shimoyama Y, Oyama T, Asano N, Oshiro A, Suzuki R, Kagami Y, Morishima Y, Nakamura S (2006)
Senile Epstein-Barr virus-associated B-cell lymphoproliferative disorders: a mini review.
J Clin Exp Hematop 46: 1-4



. Rare cases of a similar lymphoma may occur in younger individuals; however, the possibility of an undiagnosed underlying immunodeficiency must be very strongly considered in these circumstances. Cases of lymphomatoid granulomatosis , infectious mononucleosis or other well-defined disorders (such as plasmablastic lymphoma , primary effusion lymphoma and DLBCL associated with chronic inflammation ) that may be EBV+ are excluded from this category.

> Related Topics
Diffuse large B-cell lymphoma (DLBCL), NOS
Introduction: Classification of lymphoid neoplasms