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WHO Classification of Tumours
Primary cutaneous CD4 positive small/medium T-cell lymphoma


Primary cutaneous CD4-positive small/medium T-cell lymphoma is a cutaneous lymphoma characterized by a predominance of small to medium-sized CD4-positive pleomorphic T-cells without evidence of patches and plaques typical of mycosis fungoides.
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Beltraminelli H, Leinweber B, Kerl H, Cerroni L (2009)
Primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases.
Am J Dermatopathol 31: 317-22

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Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, Ralfkiaer E, Chimenti S, Diaz-Perez JL, Duncan LM, Grange F, Harris NL, Kempf W, Kerl H, Kurrer M, Knobler R, Pimpinelli N, Sander C, Santucci M, Sterry W, Vermeer MH, Wechsler J, Whittaker S, Meijer CJ (2005)
WHO-EORTC classification for cutaneous lymphomas.
Blood 105: 3768-85

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Leinweber B, Beltraminelli H, Kerl H, Cerroni L (2009)
Solitary small- to medium-sized pleomorphic T-cell nodules of undetermined significance: clinical, histopathological, immunohistochemical and molecular analysis of 26 cases.
Dermatology 219: 42-7

A majority of cases present with a solitary plaque or nodule, most commonly on the skin of head and neck.