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WHO Classification of Tumours
B lymphoblastic leukaemia/lymphoma with hyperdiploidy
Tumours of haematopoietic and lymphoid tissues


Definition

A neoplasm of lymphoblasts committed to the B lineage whose blasts contain >50 and usually <66 chromosomes, typically without translocations or other structural alterations. There is controversy as to whether specific chromosomal additions, rather than the specific number of chromosomes, should be part of the definition
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Harris MB, Shuster JJ, Carroll A, Look AT, Borowitz MJ, Crist WM, Nitschke R, Pullen J, Steuber CP, Land VJ (1992)
Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study.
Blood 79: 3316-24




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Raimondi SC, Pui CH, Hancock ML, Behm FG, Filatov L, Rivera GK (1996)
Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia.
Leukemia 10: 213-24




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Sutcliffe MJ, Shuster JJ, Sather HN, Camitta BM, Pullen J, Schultz KR, Borowitz MJ, Gaynon PS, Carroll AJ, Heerema NA (2005)
High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative.
Leukemia 19: 734-40



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> Related Topics
B lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities.
Introduction: Classification of lymphoid neoplasms