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WHO Classification of Tumours
Transient abnormal myelopoiesis associated with Down syndrome
Tumours of haematopoietic and lymphoid tissues


Definition

Transient abnormal myelopoiesis (TAM) is a unique disorder of Down syndrome (DS) newborns that presents with clinical and morphologic findings indistinguishable from AML. The blasts have morphologic and immunologic features of megakaryo­cytic lineage.

> Related Topics
Overview: Myeloid proliferations related to Down syndrome
Introduction: Myeloid Neoplasms