AML with mutated NPM1
Tumours of haematopoietic and lymphoid tissues
Acute myeloid leukaemia with mutated NPM1 carries mutations that usually involve exon 12 of the NPM1 gene. Aberrant cytoplasmic expression of nucleophosmin (NPM) is a surrogate marker of this gene mutation
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF, (2005)
. This AML type frequently has myelomonocytic or monocytic features and typically presents de novo in older adults with a normal karyotype.
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
N Engl J Med 352: 254-66
The WHO Working Group assigned this lesion to a group of provisional entities.
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Overview: AML with balanced translocations/inversions
Overview: AML with gene mutations
Acute myelomonocytic leukaemia
Acute monoblastic and monocytic leukaemia
Introduction: Myeloid Neoplasms