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WHO Classification of Tumours
AML with mutated NPM1
Tumours of haematopoietic and lymphoid tissues


Definition

Acute myeloid leukaemia with mutated NPM1 carries mutations that usually involve exon 12 of the NPM1 gene. Aberrant cytoplasmic expression of nucleophosmin (NPM) is a surrogate marker of this gene mutation
Click to access Pubmed
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF, (2005)
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
N Engl J Med 352: 254-66



. This AML type frequently has myelomonocytic or monocytic features and typically presents de novo in older adults with a normal karyotype.
The WHO Working Group assigned this lesion to a group of provisional entities.

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