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WHO Classification of Tumours
Acute myeloid leukaemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1
Tumours of haematopoietic and lymphoid tissues


Definition

Acute myeloid leukaemia with inv(3) (q21q26.2) or t(3;3)(q21;q26.2); (RPN1-EVI1) is an AML that may present de novo or arise from a prior MDS. It is often associated with normal or elevated PB platelet counts and has increased atypical BM mega­karyocytes with mono- or bi-­lobated nuclei and associated multilineage dysplasia
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Bitter MA, Neilly ME, Le Beau MM, Pearson MG, Rowley JD (1985)
Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia.
Blood 66: 1362-70




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Secker-Walker LM, Mehta A, Bain B (1995)
Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study.
Br J Haematol 91: 490-501




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Sweet DL, Golomb HM, Rowley JD, Vardiman JM (1979)
Acute myelogenous leukemia and thrombocythemia associated with an abnormality of chromosome no. 3.
Cancer Genet Cytogenet 1: 33–37.



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