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WHO Classification of Tumours
Mast cell sarcoma
Tumours of haematopoietic and lymphoid tissues


Definition

Mast cell sarcoma is extremely rare and characterized by a localized and destructive growth of highly atypical mast cells, which can be identified only after application of appropriate immunohistochemical markers, particularly anti-tryptase and anti-CD117. Although initially localized, distant spread followed by a terminal phase resembling mast cell leukaemia (MCL) is seen after a short interval. Mast cell sarcomas have been reported to occur in the larynx, large bowel, meninges, bone and skin
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Brci? L, Vuleti? LB, Stepan J, Bonevski A, Jakovljevi? G, Gasparov S, Marjanovi? K, Seiwerth S (2007)
Mast-cell sarcoma of the tibia.
J Clin Pathol 60: 424-5




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Horny HP, Parwaresch MR, Kaiserling E, Müller K, Olbermann M, Mainzer K, Lennert K (1986)
Mast cell sarcoma of the larynx.
J Clin Pathol 39: 596-602




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Kojima M, Nakamura S, Itoh H, Ohno Y, Masawa N, Joshita T, Suchi T (1999)
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon.
Mod Pathol 12: 739-43



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