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WHO Classification of Tumours
Myeloid and lymphoid neoplasms with FGFR1 abnormalities
Tumours of haematopoietic and lymphoid tissues


Definition

Haematological neoplasms with FGFR1 rearrangement are heterogeneous.They are derived from a pluripotent haemato­poietic stem cell, although in different patients or at different stages of the disease the neoplastic cells may be precursor cells or mature cells. Presentation can be as an MPN or, in transformation, as AML, T or B lineage lymphoblastic lymphoma/ leukaemia or mixed phenotype acute leukaemia (MPAL) (Table 3.04).

> Related Topics
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
Chronic eosinophilic leukaemia, NOS
Introduction: Myeloid Neoplasms