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WHO Classification of Tumours
Primary cutaneous follicle centre lymphoma
Skin


Definition

Primary cutaneous follicle centre lymphoma (PCFCL) is a malignant tumour of neoplastic follicle centre cells, including centrocytes and variable numbers of centroblasts, with a follicular, follicular and diffuse or diffuse growth pattern
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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PCFCL is the most common type of primary cutaneous B-cell lymphoma, accounting for approximately 60% of all cases. It mainly affects adults with a median age of onset of 51 years and a male:female ratio of approximately 1.5:1. It typically manifests as localized skin lesions on the scalp, the forehead or on the trunk. Approximately 5% present with skin lesions on the legs, and 15% with multifocal skin lesions

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005




Click for details
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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Irrespective of the site of involvement, cutaneous lymphomas with a diffuse growth pattern composed of large transformed B-cells are classified as primary cutaneous diffuse large B-cell lymphoma (PCLBCL), leg type .