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WHO Classification of Tumours
Refractory neutropenia
Tumours of haematopoietic and lymphoid tissues


Definition

Refractory neutropenia (RN) is a rare variant of refractory cytopenia with unilineage dysplasia. The dysplasia is generally confined to the granulocytic lineage and affects 10% or more of the neutrophils in the blood and/or bone marrow. Blasts are rarely seen in the blood and are always <1% of the white blood cells and less than 5% of the nucleated bone marrow cells. It is associated with refractory neutropenia and rarely bicytopenia.

> Related Topics
Overview: Refractory cytopenia with unilineage dysplasia
Overview: Myelodysplastic syndromes/neoplasms
Introduction: Myeloid Neoplasms