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WHO Classification of Tumours
Monoclonal B-cell lymphocytosis (MBL)
Tumours of haematopoietic and lymphoid tissues


Definition

Healthy individuals may show monoclonal or oligoclonal B-cell expansions with the characteristic phenotype of chronic lymphocytic leukaemia in about 3.5% of tested subjects >40 years old
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Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N, Schleinitz TA, Caporaso N, (2005)
Diagnostic criteria for monoclonal B-cell lymphocytosis.
Br J Haematol 130: 325-32




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Rawstron AC, Green MJ, Kuzmicki A, Kennedy B, Fenton JA, Evans PA, O'Connor SJ, Richards SJ, Morgan GJ, Jack AS, Hillmen P (2002)
Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts.
Blood 100: 635-9



. Monoclonal B-cell lymphocytosis with a non-CLL phenotype (CD5-) may correspond to similar phenomena in other B-cell neoplasms
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Amato D, Oscier DG, Davis Z, Mould S, Zheng J, Kolomietz E, Wang C (2007)
Cytogenetic aberrations and immunoglobulin VH gene mutations in clinically benign CD5- monoclonal B-cell lymphocytosis.
Am J Clin Pathol 128: 333-8



. Whether MBL is a predisposing condition or even a precursor of overt CLL has yet to be elucidated.

> Related Topics
Chronic lymphocytic leukaemia / small lymphocytic lymphoma
Introduction: Classification of lymphoid neoplasms