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WHO Classification of Tumours
Acute myeloid leukaemia with t(6;9)(p23;q34); DEK-NUP214
Tumours of haematopoietic and lymphoid tissues


Definition

Acute myeloid leukaemia with the t(6;9) (p23;q34); DEK-NUP214 is an AML with or without monocytic features that is often associated with basophilia and multilineage dysplasia
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Pearson MG, Vardiman JW, Le Beau MM, Rowley JD, Schwartz S, Kerman SL, Cohen MM, Fleischman EW, Prigogina EL (1985)
Increased numbers of marrow basophils may be associated with a t(6;9) in ANLL.
Am J Hematol 18: 393-403




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Slovak ML, Gundacker H, Bloomfield CD, Dewald G, Appelbaum FR, Larson RA, Tallman MS, Bennett JM, Stirewalt DL, Meshinchi S, Willman CL, Ravindranath Y, Alonzo TA, Carroll AJ, Raimondi SC, Heerema NA (2006)
A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies.
Leukemia 20: 1295-7



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