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WHO Classification of Tumours
Spindle cell oncocytoma
Pituitary gland


Definition

Spindle cell oncocytoma (SCO) is a rare oncocytic, non-endocrine neoplasm of the anterior hypophysis that manifests in adults and follows a benign clinical course
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Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007



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The clinical presentation and neuroimaging characteristics of patients with SCO are indistinguishable from those with a nonfunctioning pituitary adenoma. Moderate tumour volume and lack of invasion into surrounding structures generally facilitates complete surgical resection.
The eosinophilic, variably oncocytic tumour cells are immunoreactive to the anti-mitochondrial antibody 113-I, further to S-100 protein and EMA, but negative for pituitary hormones

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Roncaroli F, Scheithauer BW, Cenacchi G, Horvath E, Kovacs K, Lloyd RV, Abell-Aleff P, Santi M, Yates AJ (2002)
'Spindle cell oncocytoma' of the adenohypophysis: a tumor of folliculostellate cells?
Am J Surg Pathol 26: 1048-55



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