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WHO Classification of Tumours
Renal cell carcinoma associated with neuroblastoma


Renal cell carcinoma (RCC) associated with neuroblastoma manifests in survivors of childhood neuroblastoma. Therapy for neuroblastoma as well as genetic susceptibility may play a role in the etiology of this RCC. Tumours are histologically heterogeneous; some show a solid and papillary architecture, others show the features of small ccRCCs . Tumour sizes range from 1 and 8 cm
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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004

. Clinical outcome depends on tumor stage and the presence of high grade nuclear atypia, similar to other histologic types of renal cell carcinoma .