Renal medullary carcinoma
Renal medullary carcinoma is a rare, rapidly growing tumour of the renal medulla associated almost exclusively with sickle cell trait. It mainly affects young people (10 to 40 yrs.), particularly black patients
Wesche WA, Wilimas J, Khare V, Parham DM (1998)
, with male predominance (M/F ratio, 2:1). Tumours are poorly circumscribed ranging in size from 4 to 12 cm. Haemorrhage and necrosis are typical
Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents.
Pediatr Pathol Lab Med 18: 97-113
Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
. Metastases are frequent and the prognosis is poor.
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
IARC Press: Lyon 2004
Renal medullary carcinoma is regarded as a more aggressive variant of the carcinoma of the collecting ducts of Bellini