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WHO Classification of Tumours
Renal medullary carcinoma


Renal medullary carcinoma is a rare, rapidly growing tumour of the renal medulla associated almost exclusively with sickle cell trait. It mainly affects young people (10 to 40 yrs.), particularly black patients
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Wesche WA, Wilimas J, Khare V, Parham DM (1998)
Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents.
Pediatr Pathol Lab Med 18: 97-113

, with male predominance (M/F ratio, 2:1). Tumours are poorly circumscribed ranging in size from 4 to 12 cm. Haemorrhage and necrosis are typical
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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004

. Metastases are frequent and the prognosis is poor.

Renal medullary carcinoma is regarded as a more aggressive variant of the carcinoma of the collecting ducts of Bellini .