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WHO Classification of Tumours
Nodular lymphocyte predominant Hodgkin lymphoma
Tumours of haematopoietic and lymphoid tissues


Definition

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells) —formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. These cells reside in large spherical meshworks of follicular dendritic cell processes that are filled with non-neoplastic lymphocytes and histiocytes.

One third of the cases ­diagnosed in the past as NLPHL were lymphocyte-rich classical HL . It is currently not clear whether a purely diffuse form of NLPHL exists. Most lesions diagnosed in the past as diffuse LPHL were probably T-cell/histiocyte rich large B-cell lymphoma (TCRBCL). At present an overlap between NLPHL and TCRBCL cannot be excluded.

> Related Topics
Introduction: Hodgkin lymphomas
Classical Hodgkin lymphoma