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WHO Classification of Tumours
Anaplastic large cell lymphoma, ALK positive
Tumours of haematopoietic and lymphoid tissues


Definition

Anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK)-positive is a T-cell lymphoma consisting of lymphoid cells that are usually large with abundant cytoplasm and pleomorphic, often horseshoe-shaped nuclei, with a translocation involving the ALK gene and expression of ALK protein, and expression of CD30. ALCL with comparable morphologic and phenotypic features, but lacking ALK rearrangement and the ALK protein, is considered as a separate category, anaplastic large cell lymphoma, ALK negative (ALCL, ALK-). ALCL, ALK+ must also be distinguished from primary cutaneous anaplastic large cell lymphoma and from other subtypes of T- or B-cell lymphoma with anaplastic ­features and/or CD30 expression.

> Related Topics
Anaplastic large cell lymphoma, ALK negative
Peripheral T-cell lymphoma, (NOS)
ALK positive large B-cell lymphoma
Introduction: Classification of lymphoid neoplasms