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WHO Classification of Tumours
Mantle cell lymphoma
Tumours of haematopoietic and lymphoid tissues


Definition

Mantle cell lymphoma (MCL) is a B-cell neoplasm generally composed of mono­morphic small to medium-sized lymphoid cells with irregular nuclear contours and a CCND1 translocation
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Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES (1992)
Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data.
Am J Surg Pathol 16: 637-40




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Campo E, Raffeld M, Jaffe ES (1999)
Mantle-cell lymphoma.
Semin Hematol 36: 115-27




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Lardelli P, Bookman MA, Sundeen J, Longo DL, Jaffe ES (1990)
Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations.
Am J Surg Pathol 14: 752-63




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Lennert K, Stein H, Kaiserling E (1975)
Cytological and functional criteria for the classification of malignant lymphomata.
Br J Cancer Suppl 2: 29-43




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Parry-Jones N, Matutes E, Morilla R, Brito-Babapulle V, Wotherspoon A, Swansbury GJ, Catovsky D (2007)
Cytogenetic abnormalities additional to t(11;14) correlate with clinical features in leukaemic presentation of mantle cell lymphoma, and may influence prognosis: a study of 60 cases by FISH.
Br J Haematol 137: 117-24




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Swerdlow SH, Habeshaw JA, Murray LJ, Dhaliwal HS, Lister TA, Stansfeld AG (1983)
Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse.
Am J Pathol 113: 181-97




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Tolksdorf G, Stein H, Lennert K (1980)
Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes).
Br J Cancer 41: 168-82



. Neoplastic trans­formed cells (centroblasts), paraimmuno­blasts and proliferation centres are absent.

> Variant
"In situ" mantle cell lymphoma

> Related Topics
Introduction: Classification of lymphoid neoplasms