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WHO Classification of Tumours
Follicular lymphoma
Tumours of haematopoietic and lymphoid tissues


Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially follicular pattern. If diffuse areas of any size comprised predominantly or entirely of blastic cells are present in any case of follicular lymphoma, a diagnosis of diffuse large B-cell lymphoma is also made. Lymphomas composed of centrocytes and centroblasts with an entirely diffuse pattern in the sampled tissue may be included in this category. Primary cutaneous follicle centre lymphomas are separately classified
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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005

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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008


> Variants
Paediatric follicular lymphoma
Primary intestinal follicular lymphoma
Intrafollicular neoplasia/"In situ" follicular lymphoma
Other extranodal follicular lymphomas. Follicular lymphomas can occur in almost any extranodal site

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Ferry JA, Fung CY, Zukerberg L, Lucarelli MJ, Hasserjian RP, Preffer FI, Harris NL (2007)
Lymphoma of the ocular adnexa: A study of 353 cases.
Am J Surg Pathol 31: 170-84

. In many of these sites, the morphology, immuno phenotype and genetic features appear to be similar to those of nodal FL, although data are sparse. Despite this, patients usually have localized extranodal disease, and systemic relapses are uncommon. Testicular follicular lymphomas are reported with increased frequency in children but also are reported in adults
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Bacon CM, Ye H, Diss TC, McNamara C, Kueck B, Hasserjian RP, Rohatiner AZ, Ferry J, Du MQ, Dogan A (2007)
Primary follicular lymphoma of the testis and epididymis in adults.
Am J Surg Pathol 31: 1050-8


> Related Topics
Primary cutaneous follicle centre lymphoma
Introduction: Classification of lymphoid neoplasms