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WHO Classification of Tumours
Sex cord-gonadal stromal tumor, NOS
Adrenal gland


Sex cord-gonadal stromal tumor of the adrenal gland is a very rare tumour with sex cord-stromal differentiation, arising in the adrenal gland
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Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004


It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the neoplasm or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, 10% of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group.
It only occured in post-menopausal women and the histogenesis stays unclear.