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WHO Classification of Tumours
Teratoma, NOS
Thyroid gland


Definition

A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach. According to the level of differentiation of the tissues which comprise the tumor, they are classified as mature teratoma or immature teratoma .

There are approximately 300 cases of thyroid teratomas reported, representing less than 0.1% of all thyroid gland neoplasms. Approximately 50% of cases manifest in newborns; occurrence in adults is very unusual

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Grosfeld JL, Ballantine TV, Lowe D, Baehner RL (1976)
Benign and malignant teratomas in children: analysis of 85 patients.
Surgery 80: 297-305




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Jordan RB, Gauderer MW (1988)
Cervical teratomas: an analysis. Literature review and proposed classification.
J Pediatr Surg 23: 583-91




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Tapper D, Lack EE (1983)
Teratomas in infancy and childhood. A 54-year experience at the Children's Hospital Medical Center.
Ann Surg 198: 398-410



. There is generally no gender predilection, though malignant teratomas may occur more frequently in males
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Thompson LD, Rosai J, Heffess CS (2000)
Primary thyroid teratomas: a clinicopathologic study of 30 cases.
Cancer 88: 1149-58



. Among neonates and infants, there is a near absence of malignant behaviour, but thyroid teratomas can cause significant morbidity due to respiratory distress or the presence of associated malformation of vital structures in the neck
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Kooijman CD (1988)
Immature teratomas in children.
Histopathology 12: 491-502




Click to access Pubmed
Thompson LD, Rosai J, Heffess CS (2000)
Primary thyroid teratomas: a clinicopathologic study of 30 cases.
Cancer 88: 1149-58



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