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WHO Classification of Tumours
Follicular adenoma
Thyroid gland


Definition

A benign, encapsulated thyroid tumor with evidence for follicular cell differentiation that may be associated with thyroid hormone secretion. Follicular adenomas predominantly composed of oncocytic cells have been designated Hurthle cell adenoma . Several additional histological variants have been recognized
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Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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The epidemiology of follicular adenoma is difficult to analyse because of the lack of consistent criteria for distinguishing hyperplastic nodules and adenomas. Solitary cold thyroid nodules occur in 47% of adults in an iodine sufficient area

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Klonoff DC, Greenspan FS (1982)
The thyroid nodule.
Adv Intern Med 27: 101-26



; in iodine deficient areas, the incidence of nodules, usually multiple, can rise to 50% of the population. Females are more commonly affected than males. Radiation-induced adenomas show a very long mean latent period
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Shore RE, Hildreth N, Dvoretsky P, Pasternack B, Andresen E (1993)
Benign thyroid adenomas among persons X-irradiated in infancy for enlarged thymus glands.
Radiat Res 134: 217-23



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