logo logo
Search: Organ site Search: Tumor / Syndrome
or
WHO Classification of Tumours
Spindle epithelial tumor with thymus-like element
Thyroid gland


Definition

A rare, slow growing, primary carcinoma of the thyroid gland characterized by a lobulated architectural pattern and the presence of a biphasic cellular population composed of spindle epithelial cells and glandular cells
Click for details
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



. A small number of cases are composed exclusively of spindle epithelial cells or glandular cells
Click to access Pubmed
Chetty R, Goetsch S, Nayler S, Cooper K (1998)
Spindle epithelial tumour with thymus-like element (SETTLE): the predominantly monophasic variant.
Histopathology 33: 71-4



.

Spindle cell tumour with thymus-like differentiation (SETTLE) usually affects children, adolescents and young adults, with a mean age of 19 years (range 4-59), and a male predominance

Click to access Pubmed
Bradford CR, Devaney KO, Lee JI (1999)
Spindle epithelial tumor with thymus-like differentiation: a case report and review of the literature.
Otolaryngol Head Neck Surg 120: 603-6




Click to access Pubmed
Hofman P, Mainguené C, Michiels JF, Pages A, Thyss A (1995)
Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor). An immunohistochemical and electron microscopic study.
Eur Arch Otorhinolaryngol 252: 316-20




Click to access Pubmed
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y (2002)
Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid.
Head Neck 24: 888-93



. SETTLE is typically associated with delayed blood-borne metastasis. Metastasis usually occurs many years after diagnosis
Click to access Pubmed
Chan JK, Rosai J (1991)
Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept.
Hum Pathol 22: 349-67



, although regional metastasis at presentation can sometimes be present. The overall metastatic rate is over 60% with long-term follow-up
Click to access Pubmed
Cheuk W, Jacobson AA, Chan JK (2000)
Spindle epithelial tumor with thymus-like differentiation (SETTLE): a distinctive malignant thyroid neoplasm with significant metastatic potential.
Mod Pathol 13: 1150-5



. Metastatic disease, nevertheless, can still be compatible with long survival after treatment
Click for details
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



.