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WHO Classification of Tumours
Squamous cell carcinoma, NOS
Thyroid gland


Definition

A carcinoma arising from squamous epithelial cells, morphologically characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Typical sites of squamous cell carcinomas include the head and neck region, repiratory tract, skin and cervix. Distant metastases occur in approximately 20% of cases.

Squamous cell carcinoma of the thyroid is a disease of the elderly and more common in women, with a female to male ratio of 2:1

Click to access Pubmed
Lam KY, Lo CY, Liu MC (2001)
Primary squamous cell carcinoma of the thyroid gland: an entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles.
Histopathology 39: 279-86



. The prognosis in most cases is similar to that of undifferentiated carcinoma
Click to access Pubmed
Cook AM, Vini L, Harmer C (1999)
Squamous cell carcinoma of the thyroid: outcome of treatment in 16 patients.
Eur J Surg Oncol 25: 606-9




Click to access Pubmed
Lam KY, Lo CY, Liu MC (2001)
Primary squamous cell carcinoma of the thyroid gland: an entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles.
Histopathology 39: 279-86




Click for details
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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