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WHO Classification of Tumours
Papillary adenocarcinoma, NOS
Thyroid gland


Papillary adenocarcinoma of the thyroid is a malignant epithelial tumour histologically characterized by follicular cell differentiation, distinctive nuclear features and a papillary growth pattern. Papillary carcinomas are reactive for
cytokeratins, thyroglobulin and thyroid
transcription factor–1 (TTF-1)Most tumours manifest in adults of 20-50 years, with a female to male ratio of 4:1. The overall survival is greater than 90%, particularly for patients younger than 45 years. Although this neoplasm is rare before the age of 15 years, it represents the most common paediatric thyroid malignancy. The etiology of papillary thyroid carcinoma is closely linked to radiation exposure

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Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004