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WHO Classification of Tumours
Neuroendocrine carcinoma, NOS
Kidney


Definition

Neuroendocrine carcinoma is a poorly-differentiated malignant epithelial neoplasm with signs of neuroendocrine differentiation
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Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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In the kidney, these tumours are usually located close to the renal pelvis, often surrounding the pelvicaliceal cavities and/or extending into renal sinus adipose tissue. They are histologically composed of sheets, nests and trabeculae of small, round to fusiform cells separated by stroma. Mitotic activity is high, vascular tumour embolism common, and tumour necrosis often extensive and accompanied by perivascular DNA deposition (Azzopardi phenomenon). A concomitant urothelial carcinoma is frequently found.
Neuroendocrine carcinoma of the kidney occurs in adults (mean age 60 years, no sex predilection). The prognosis is poor and stage dependent. Regional lymph node as well as distant metastases are common. More than 75% of patients succumb within one year of diagnosis

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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



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