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WHO Classification of Tumours
Malignant fibrous histiocytoma
Kidney


Definition

Malignant fibrous histiocytoma (MFH) is a pleomorphic sarcoma characterized by the presence of fibrohistiocytic cells and spindle cells arranged in a storiform pattern. According to the 2003 WHO Classification
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



, this term is now used as a diagnosis of exclusion for sarcomas composed largely of myofibroblasts or undifferentiated mesenchymal cells} and isn synonymous with undifferentiated high grade pleomorphic sarcoma.

Renal malignant fibrous histiocytomas are very rare tumours thought to arise from the renal capsule. They are large and fleshy masses with haemorrhage and necrosis. MFHs usually have pararenal and retroperitoneal extension and may extend into the renal and caval veins

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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



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