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WHO Classification of Tumours
Oncocytoma
Kidney


Definition

Renal oncocytoma is a benign, well-circumscribed, non-encapsulated neoplasm of the renal epithelium thought to arise from intercalated cells. It is histologically characterized by solid compact nests, acini, tubules, or microcysts (the latter may be filled with red blood cells) and often associated with a hypocellular hyalinized stroma. The predominant cell type is the "oncocyte", a large cell with densely granular and mitochondria-rich eosinophilic cytoplasm
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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



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Renal oncocytomas affect males almost twice as often as females and show a peak incidence in the seventh decade of life. They are benign neoplasms without tendency for metastatic spread.