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WHO Classification of Tumours
Papillary adenocarcinoma, NOS
Kidney


Definition

Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.

Papillary renal cell carcinomas account for approximately 10% of malignant renal parenchymal tumours in adults. The following morphological types of pRCC are distinguished

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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004




Click to access Pubmed
Srigley JR, Delahunt B (2009)
Uncommon and recently described renal carcinomas.
Mod Pathol 22 Suppl 2: S2-S23



:

> Type 1 papillary renal cell carcinomas have papillae covered by small cells with scanty cytoplasm, arranged in a single layer on the papillary basement membrane. They are are more frequently multifocal and a key component of the autosomal dominant hereditary papillary renal carcinoma (HPRC) syndrome.

> Type 2 papillary renal cell carcinomas often have cells of higher nuclear grade with eosinophilic cytoplasm and pseudostratified nuclei on papillary cores. They constitute the renal manifestation of the dominant hereditary leiomyomatosis and renal cell cancer (HLRCC)

Click for details
Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



.

> Clear cell papillary and cystic renal cell carcinoma typically manifests in patients with cystic or non-cystic end-stage renal disease (ESRD)

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Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, Moch H, Amin MB (2006)
Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia.
Am J Surg Pathol 30: 141-53



, but alo in otherwise unaffected kidneys. It is histologicall caracterized by papillary structures lined by cells with clear cytoplasm which typically occur within cysts that are also lined by clear epithelial cells
Click to access Pubmed
Srigley JR, Delahunt B (2009)
Uncommon and recently described renal carcinomas.
Mod Pathol 22 Suppl 2: S2-S23



.

> Oncocytic papillary renal cell carcinoma
This more recently identified variant of pRCC

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Lefevre M, Couturier J, Sibony M, Bazille C, Boyer K, Callard P, Vieillefond A, Allory Y (2005)
Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases.
Am J Surg Pathol 29: 1576-81



with strong preference for males is histologically characterized by a papillary architecture, with tumour cells exhibiting oncocytic features, i.e. a large, intensely eosinophilic cytoplasm
Click to access Pubmed
Srigley JR, Delahunt B (2009)
Uncommon and recently described renal carcinomas.
Mod Pathol 22 Suppl 2: S2-S23



.