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WHO Classification of Tumours
Nephroblastoma, NOS
Kidney


Definition

This malignant embryonal pediatric tumour manifests predominantly in the kidney (Wilms tumour). Microscopically, this triphasic tumour is composed of metanephric blastema, epithelial structures consisting of tubular and/or glomerular structures, and mesenchymal elements
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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



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> Nephrogenic rests and nephroblastomatosis
Nephrogenic rests are abnormally persistent foci of embryonal cells that are capable of developing into nephroblastomas and are found in up to 40% of nephroblastoma patients. According to their location, they are classified as perilobar (PLNR) and intralobar (ILNR) nephrogenic rests

Click for details
Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



.
Nephroblastomatosis is defined as the presence of diffuse or multifocal nephrogenic rests.