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WHO Classification of Tumours
Clear cell renal cell carcinoma
Kidney


Definition

Clear cell renal cell carcinoma is the most common malignant neoplasm of the kidney in adults
Click to access Pubmed
Cohen HT, McGovern FJ (2005)
Renal-cell carcinoma.
N Engl J Med 353: 2477-90



. It is derived from epithelia of the renal tubules, composed of cells with clear or eosinophilic cytoplasm
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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



and is the typical renal manifestation of the dominantly inherited von Hippel-Lindau syndrome .