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WHO Classification of Tumours
Renal cell carcinoma, NOS
Kidney


Definition

The term renal cell carcinoma (RCC) comprises a group of malignant kidney tumours derived from the epithelium of the renal tubules
Click to access Pubmed
Kovacs G, Akhtar M, Beckwith BJ, Bugert P, Cooper CS, Delahunt B, Eble JN, Fleming S, Ljungberg B, Medeiros LJ, Moch H, Reuter VE, Ritz E, Roos G, Schmidt D, Srigley JR, Störkel S, van den Berg E, Zbar B (1997)
The Heidelberg classification of renal cell tumours.
J Pathol 183: 131-3




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Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004




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Srigley JR, Delahunt B (2009)
Uncommon and recently described renal carcinomas.
Mod Pathol 22 Suppl 2: S2-S23



. There are several distinct variants that differ in histopathology and, to some extent, in clinical manifestation and genetic susceptibility:

> Clear cell renal cell carcinoma
> Papillary renal cell carcinomas
> Chromophobe renal cell carcinoma
> Multilocular clear cell renal cell carcinoma
> Carcinoma of the collecting ducts of Bellini
> Renal medullary carcinoma
> Acquired cystic disease-associated renal cell carcinoma
> Renal Xp11 translocation carcinoma
> Post-neuroblastoma renal cell carcinoma
> Renal mucinous tubular and spindle cell carcinoma
> Follicualr renal cell carcinoma
> Leiomyomatous renal cell carcinoma

The term renal cell carcinoma, NOS / Unclassified should be used for lesions which histopathologically do not correspond to any of the above variants. They have been estimated to amount to less than 5% of renal cell carcinomas.