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WHO Classification of Tumours
Bowen disease


Bowen disease is a form of squamous cell carcinoma in situ . It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. Histologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact.
Bowen disease affects predominantly white males in their 6-8th decades of life. UV damage and ingestion of inorganic arsenic may play an etiological role. On the skin surface, it presents as a single or multiple erythematous, scaly, keratotic patches or plaques. Complete surgical removal is the treatment of choice and usually curative.

The clinical entity of queyrat erythroplasia is regarded as Bowen disease of the penis and it presents as an asymptomatic, red, circumscribed plaque.