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WHO Classification of Tumours
Merkel cell carcinoma


Merkel cell carcinoma (MCC) is a rare, highly malignant primary cutaneous neoplasm with neuroendocrine and epithelial differentiation
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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005

This tumour typically occurs on the sun-exposed skin of elderly patients, with a preference for males. Immunosuppression is a known risk factor. Recent evidence points to a causation by infection with Merkel cell polyomavirus (MCPyV)

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Feng H, Shuda M, Chang Y, Moore PS (2008)
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
Science 319: 1096-100

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Kassem A, Schöpflin A, Diaz C, Weyers W, Stickeler E, Werner M, Zur Hausen A (2008)
Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene.
Cancer Res 68: 5009-13