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WHO Classification of Tumours
Placental site trophoblastic tumor
Corpus uteri


Definition

Placental site trophoblastic tumour is a rare gestational neoplasm characterized by a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts. There is no significant population of syncytiotrophoblasts. The neoplastic cells are medium-sized to large, mononuclear or multinucleated. They are characterized by mild to marked nuclear atypia, prominent nucleoli, eosinophilic to clear cytoplasm, scattered mitoses and occasional intranuclear inclusions. The tumour infiltrates the myometrium and vessels in a manner similar to the implantation site trophoblast.
Major adverse prognostic variable for placental site trophoblastic tumours is a long (>4 years) interval from the last antecedent pregnancy

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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