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WHO Classification of Tumours
Choriocarcinoma, NOS
Corpus uteri


Definition

Choriocarcinoma is an aggressive malignant tumour composed of large sheets of highly atypical trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Gestational choriocarcinoma may occur subsequent to a molar pregnancy (50% of cases), an abortion (25%), a normal gestation (22.5%) or an ectopic pregnancy (2.5%). Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion. The tumour lacks stroma and vessels; the viable tumour is correspondingly located at the periphery of haemorrhagic foci. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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