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WHO Classification of Tumours
Adenosarcoma
Corpus uteri


Definition

Adenosarcoma is a low-grade malignant neoplasm of the female genital tract characterized by the presence of a benign epithelial component (tubular and cleft-like glands) and a low grade sarcomatous component that contains varying amounts of fibrous and smooth muscle tissues. In a minority of cases, the sarcomatous component contains heterologous elements including striated muscle, cartilage, and fat.
Uterine adenosarcomas typically are exophytic polypoid masses that extend into the uterine cavity. In most cases, the tumours do not invade the myometrium.
Adenosarcoma affects women of all ages. Patients typically present with abnormal vaginal bleeding, an enlarged uterus and tissue protruding from the external os. The tumour recurs in approximately 25-40% of cases, most commonly in the pelvis or vagina. Distant metastases have been reported in 5% of cases. Poor prognostic factors are extrauterine spread, deep myometrial invasion into the outer half of the myometrium and sarcomatous overgrowth. Recurrences may occur after many years, making longterm follow-up necessary

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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