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WHO Classification of Tumours
Carcinosarcoma, NOS
Corpus uteri


Definition

Carcinosarcoma is a malignant tumour composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with divergent lines of differentiation.
Uterine carcinosarcomas typically present as polypoid, bulky, necrotic and haemorrhagic neoplasms that fill the endometrial cavity and invade deeply into the myometrium, often extending beyond the uterus. The uterus is enlarged. The epithelial and mesenchymal components are sharply demarcated in most cases. The epithelial element is typically glandular. Eosinophilic hyaline inclusions are frequent, especially in the mesenchymal components.
Carcinosarcomas predominantly arise in elderly postmenopausal women (median age 65 years). The most common symptom is vaginal bleeding. The clinical course is usually aggressive, the overall prognosis is poor. Recurrences are common. Carcinosarcomas primarily spread via lymphatics. They frequently develop intra-abdominal and retroperitoneal nodal metastases. The prognosis for tumours confined to an otherwise benign polyp appears to be sligthly better

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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