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WHO Classification of Tumours
Leiomyomatosis, NOS
Corpus uteri


Definition

> Diffuse leiomyomatosis is an unusual growth pattern variant of leiomyoma characterized by innumerable small (typically <1cm in diameter) smooth muscle nodules scattered throughout the uterine corpus, resulting in symmetrical enlargement of the uterus
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Clement PB, Young RH (1987)
Diffuse leiomyomatosis of the uterus: a report of four cases.
Int J Gynecol Pathol 6: 322-30



. The tumour nodules consist of uniform, bland, spindle-shaped smooth muscle cells. They are less well circumscribed than leiomyomas. The condition is benign, but it may be complicated by haemorrhage
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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> Intravenous leiomyomatosis is a very rare growth pattern variant of leiomyoma characterized by nodules and cords of benign smooth muscle cells proliferating in venous channels outside the boundaries of a leiomyoma

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Norris HJ, Parmley T (1975)
Mesenchymal tumors of the uterus. V. Intravenous leiomyomatosis. A clinical and pathologic study of 14 cases.
Cancer 36: 2164-78



. Convoluted, worm-like extensions into the uterine veins in the broad ligament or into other pelvic veins are frequent; the growth may also extend into the vena cava or the right heart. Histologically, the tumours are highly variable and may contain cellular, atypical, epithelioid or lipoleiomyomatous smooth muscle. Prominent zones of fibrosis or hyalinization are typical
Click for details
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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